Micronized
purified flavonoid fraction (MPFF) Tablets Diosmin and Hespiridin
Daflon is a micronized purified flavonoid fraction containing 90% diosmin and 10% other flavonoids expressed as hesperidin.
Daflon is a micronized purified flavonoid fraction containing 90% diosmin and 10% other flavonoids expressed as hesperidin.
DIOSMN
450MG + HESPIRIDIN 50MG TABLET
(http://www.webmd.com/default.htm)
Class:
a type of plant chemical found mainly in citrus fruits.
Indications:
Internal
hemorrhoids, when used in combination with diosmin. The combination of
hesperidinand
diosmin seems to both significantly improve symptoms of hemorrhoids and also
keep hemorrhoids,
once healed, from coming back.
Treating
leg ulcers caused by poor circulation, when used in combination with diosmin.
Hesperidin,
in combination with diosmin and a compression dressing, seems to improve
healing
of small ulcers (less than 10 cm) caused by poor blood circulation.
Available
dosage form in the hospital:
Diosmin and Hespiridin TABLET
Trade
Names:
Dosage:
BY
MOUTH:
For the treatment of internal hemorrhoids: 1350 mg of
diosmin plus 150 mg of hesperidin
twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin
twice daily for 3 days. Some researchers also try 600 mg of diosmin three times
daily for 4 days, followed by 300 mg twice daily for 10 days, in combination with
11 grams of psyllium daily. However, this lower diosmin dose does not seem to be
as effective.
For prevention of relapse internal hemorrhoids: 450
mg of diosmin plus 50 mg of hesperidin
twice daily for 3 months of therapy.
For the treatment of leg wounds due to bloodflow
problems (venous stasis ulcers): the combination
of 900 mg of diosmin and 100 mg of hesperidin daily has been used for up
to 2 months.
Common
side effect: Diosmin is safe for most people when used short-term for up to
three months.
It can cause some side effects such as stomach and abdominal pain, diarrhea,
and headache.
Do
not take diosmin for more than three months without medical supervision.
Pregnancy
Risk Factor:
Not
enough is known about the use of diosmin during pregnancy and breast-feeding.
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Indications
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Listed
in Dosage.
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Adult : PO Chronic venous disease Per tab
contains diosmin 450 mg and hesperidin 50 mg: 2 tab/day. Haemorrhoids Per
tab contains diosmin 450 mg and hesperidin 50 mg: Acute attack: 6 tab/day for
1st 4 days, followed by 4 tab/day for next 3 days; Chronic haemorrhoids: 2
tab/day.
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Oral
Haemorrhoids
Adult: Each tablet containing diosmin 450 mg and
hesperidin 50 mg. Acute attack: 6 tablets daily for the 1st 4 days followed
by 4 tablets daily for the next 3 days. Chronic haemorrhoids: 2 tablets
daily.
Oral Chronic venous disease
Adult: Each tablet containing disomin 450 mg and
hesperidin 50 mg: 2 tablets daily.
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Lactation.
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GI
discomfort.
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Metabolism
of metronidazole may be reduced by concurrent admin of diosmin.
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Description: Diosmin and
hesperidin are flavonoid compounds. When used together, they prolong the
vasoconstrictor effect of noradrenaline on the venous wall, thus increasing
venous return and reducing venous hyperpressure present in patients with
chronic venous disease. They also improve lymphatic drainage and protect the
microcirculation from inflammation. Diosmin and hesperidin are used together
in the treatment of venous disease e.g. chronic venous disease and
haemorrhoidal disease.
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Disclaimer:
This information is independently developed by MIMS based on Diosmin + Hesperidin
from various references and is provided for your reference only. Therapeutic
uses and prescribing information may vary between countries. Please refer to
MIMS Product Monographs for specific and locally approved prescribing
information. Although great effort has been made to ensure content accuracy,
MIMS shall not be held responsible or liable for any claims or damages
arising from the use or misuse of the information contained herein, its
contents or omissions, or otherwise. Copyright © 2016 MIMS. All rights
reserved. Powered by MIMS.com
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